<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fd8b5-a2ae-71b6-b632-564100625e0b,g:fb5c4ade-8c7d-42cb-a61d-9391e9479ef0-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.cvrx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="cvrx-20260930.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd8b5-a357-7513-908e-d889cb493a8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019fd8b5-a357-77fb-a69a-87687cb79ec9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8b5-a357-7513-908e-d889cb493a8d" xlink:to="loc_us-gaap_AccountsPayableCurrent_019fd8b5-a357-77fb-a69a-87687cb79ec9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7388-8900-4167df2b78af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd8b5-a357-7513-908e-d889cb493a8d" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7388-8900-4167df2b78af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd8b5-a357-70a1-b1ee-27b84c501bda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd8b5-a357-717d-8d79-0f4f23aca522" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8b5-a357-70a1-b1ee-27b84c501bda" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd8b5-a357-717d-8d79-0f4f23aca522" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019fd8b5-a357-7a5b-88d7-2ebad99244d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8b5-a357-70a1-b1ee-27b84c501bda" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019fd8b5-a357-7a5b-88d7-2ebad99244d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd8b5-a357-7793-8003-270d2d1cf523" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8b5-a357-70a1-b1ee-27b84c501bda" xlink:to="loc_us-gaap_InventoryNet_019fd8b5-a357-7793-8003-270d2d1cf523" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8b5-a357-7f4e-a992-d3eaa4430cdf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd8b5-a357-70a1-b1ee-27b84c501bda" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd8b5-a357-7f4e-a992-d3eaa4430cdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fd8b5-a357-778c-a13d-8cf704a02600" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd8b5-a357-7493-abd6-2b670d6a1d0f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd8b5-a357-778c-a13d-8cf704a02600" xlink:to="loc_us-gaap_LiabilitiesCurrent_019fd8b5-a357-7493-abd6-2b670d6a1d0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fd8b5-a357-7dc0-b265-0e60a5c4fae7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd8b5-a357-778c-a13d-8cf704a02600" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fd8b5-a357-7dc0-b265-0e60a5c4fae7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019fd8b5-a357-7aea-8654-cb6c524e9638" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd8b5-a357-778c-a13d-8cf704a02600" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019fd8b5-a357-7aea-8654-cb6c524e9638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8b5-a357-7985-8f2a-2b4eef98c8cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd8b5-a357-778c-a13d-8cf704a02600" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd8b5-a357-7985-8f2a-2b4eef98c8cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8b5-a357-730e-b9dc-1d8f98d9a85f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fd8b5-a357-7390-b4d7-aeac7e3e5cf1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8b5-a357-730e-b9dc-1d8f98d9a85f" xlink:to="loc_us-gaap_Liabilities_019fd8b5-a357-7390-b4d7-aeac7e3e5cf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019fd8b5-a357-7643-be42-ee22b171296c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8b5-a357-730e-b9dc-1d8f98d9a85f" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019fd8b5-a357-7643-be42-ee22b171296c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd8b5-a357-7153-b4d8-e950cecd21d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd8b5-a357-730e-b9dc-1d8f98d9a85f" xlink:to="loc_us-gaap_StockholdersEquity_019fd8b5-a357-7153-b4d8-e950cecd21d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019fd8b5-a357-7f56-a887-27fb02b9a356" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd8b5-a357-795d-8580-ebee5ee52f39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8b5-a357-7f56-a887-27fb02b9a356" xlink:to="loc_us-gaap_AssetsCurrent_019fd8b5-a357-795d-8580-ebee5ee52f39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd8b5-a357-755b-8eb4-ab34bd01e9e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8b5-a357-7f56-a887-27fb02b9a356" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd8b5-a357-755b-8eb4-ab34bd01e9e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019fd8b5-a357-7255-9081-88dd946e5d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8b5-a357-7f56-a887-27fb02b9a356" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019fd8b5-a357-7255-9081-88dd946e5d5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019fd8b5-a357-7702-92ec-2382db25c771" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd8b5-a357-7f56-a887-27fb02b9a356" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019fd8b5-a357-7702-92ec-2382db25c771" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd8b5-a357-7481-8f91-96a7008881ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019fd8b5-a357-711c-a61f-4ebcc7c77281" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8b5-a357-7481-8f91-96a7008881ea" xlink:to="loc_us-gaap_CommonStockValue_019fd8b5-a357-711c-a61f-4ebcc7c77281" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019fd8b5-a357-7146-982d-7758d576fb96" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8b5-a357-7481-8f91-96a7008881ea" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019fd8b5-a357-7146-982d-7758d576fb96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd8b5-a357-7718-9f07-03d71d5619d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8b5-a357-7481-8f91-96a7008881ea" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd8b5-a357-7718-9f07-03d71d5619d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd8b5-a357-7778-89e6-a20f1bf50f5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd8b5-a357-7481-8f91-96a7008881ea" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd8b5-a357-7778-89e6-a20f1bf50f5c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="cvrx-20260930.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8b5-a357-7b87-8aa2-a5eee87e0132" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019fd8b5-a357-7fc6-9e91-23d80a1b1b08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8b5-a357-7b87-8aa2-a5eee87e0132" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019fd8b5-a357-7fc6-9e91-23d80a1b1b08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd8b5-a357-78b9-bf33-1bd9f7ee452a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8b5-a357-7b87-8aa2-a5eee87e0132" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fd8b5-a357-78b9-bf33-1bd9f7ee452a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fd8b5-a357-79ba-a55c-26a97fec6fef" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8b5-a357-7b87-8aa2-a5eee87e0132" xlink:to="loc_us-gaap_OperatingIncomeLoss_019fd8b5-a357-79ba-a55c-26a97fec6fef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019fd8b5-a357-7c02-aca0-f2768a8aad16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd8b5-a357-7a54-8d75-57b07ea3ed1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fd8b5-a357-7c02-aca0-f2768a8aad16" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd8b5-a357-7a54-8d75-57b07ea3ed1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019fd8b5-a357-72b8-bdaf-f61eaf4dbc7a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019fd8b5-a357-7c02-aca0-f2768a8aad16" xlink:to="loc_us-gaap_CostOfRevenue_019fd8b5-a357-72b8-bdaf-f61eaf4dbc7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fd8b5-a357-7e74-a99d-0317110140ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019fd8b5-a357-7f4f-8a32-21011e221233" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8b5-a357-7e74-a99d-0317110140ae" xlink:to="loc_us-gaap_GrossProfit_019fd8b5-a357-7f4f-8a32-21011e221233" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019fd8b5-a357-72f0-ad59-0d8cb71de204" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd8b5-a357-7e74-a99d-0317110140ae" xlink:to="loc_us-gaap_OperatingExpenses_019fd8b5-a357-72f0-ad59-0d8cb71de204" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019fd8b5-a357-757b-b1d3-5dcd37d9448c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8b5-a357-7de1-ab7e-6d95808366d9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019fd8b5-a357-757b-b1d3-5dcd37d9448c" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019fd8b5-a357-7de1-ab7e-6d95808366d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8b5-a357-7ff8-8643-eb6a006d23af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019fd8b5-a357-757b-b1d3-5dcd37d9448c" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd8b5-a357-7ff8-8643-eb6a006d23af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fd8b5-a357-7df6-be38-10bc5cd7962a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019fd8b5-a357-7e73-bc40-ff0c251a6be5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fd8b5-a357-7df6-be38-10bc5cd7962a" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019fd8b5-a357-7e73-bc40-ff0c251a6be5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8b5-a357-7c00-9dd1-342c363f7b09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fd8b5-a357-7df6-be38-10bc5cd7962a" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd8b5-a357-7c00-9dd1-342c363f7b09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd8b5-a357-7a7a-82ea-88272919302b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fd8b5-a357-7779-bd95-ce15388a0671" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd8b5-a357-7a7a-82ea-88272919302b" xlink:to="loc_us-gaap_NetIncomeLoss_019fd8b5-a357-7779-bd95-ce15388a0671" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019fd8b5-a357-774e-96d0-1a32d43ac04b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd8b5-a357-7a7a-82ea-88272919302b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019fd8b5-a357-774e-96d0-1a32d43ac04b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="cvrx-20260930.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8b5-a357-786c-b881-46e4aa3f617b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd8b5-a357-7a3e-a7bb-c5afe22c59b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8b5-a357-786c-b881-46e4aa3f617b" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd8b5-a357-7a3e-a7bb-c5afe22c59b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7144-8d3c-4eecdf118bf4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019fd8b5-a357-7845-8fbf-3a35c0cbe76f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7144-8d3c-4eecdf118bf4" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019fd8b5-a357-7845-8fbf-3a35c0cbe76f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_019fd8b5-a357-76e0-a33f-5ff4e4f0b65a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7144-8d3c-4eecdf118bf4" xlink:to="loc_us-gaap_ProceedsFromStockPlans_019fd8b5-a357-76e0-a33f-5ff4e4f0b65a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019fd8b5-a357-75a6-bcc3-e5873ad3a545" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7144-8d3c-4eecdf118bf4" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019fd8b5-a357-75a6-bcc3-e5873ad3a545" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLongTermLinesOfCredit_019fd8b5-a357-7c6e-a960-fd645b383a38" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromLongTermLinesOfCredit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7144-8d3c-4eecdf118bf4" xlink:to="loc_us-gaap_ProceedsFromLongTermLinesOfCredit_019fd8b5-a357-7c6e-a960-fd645b383a38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_019fd8b5-a357-78ba-a64e-216f214b359e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7144-8d3c-4eecdf118bf4" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_019fd8b5-a357-78ba-a64e-216f214b359e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8b5-a357-791f-8b2e-2206bbf20f93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7e32-9fbb-8ce19bbafa1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8b5-a357-791f-8b2e-2206bbf20f93" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd8b5-a357-7e32-9fbb-8ce19bbafa1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8b5-a357-7e7e-962f-b6cc319ea7ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8b5-a357-791f-8b2e-2206bbf20f93" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd8b5-a357-7e7e-962f-b6cc319ea7ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7940-bab7-0944ea53a11d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8b5-a357-791f-8b2e-2206bbf20f93" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7940-bab7-0944ea53a11d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8b5-a357-7250-8746-42493f2ad951" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fd8b5-a357-791f-8b2e-2206bbf20f93" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fd8b5-a357-7250-8746-42493f2ad951" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fd8b5-a357-7f74-a976-33ad92e8a2bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_ProfitLoss_019fd8b5-a357-7f74-a976-33ad92e8a2bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019fd8b5-a357-763e-8fd4-d4bd2cc6354f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_ShareBasedCompensation_019fd8b5-a357-763e-8fd4-d4bd2cc6354f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019fd8b5-a357-7078-a9dc-18acacc17271" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_Depreciation_019fd8b5-a357-7078-a9dc-18acacc17271" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019fd8b5-a357-7a21-acb3-e723e49f08e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019fd8b5-a357-7a21-acb3-e723e49f08e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019fd8b5-a357-7a7c-8893-e6575aa4cb5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019fd8b5-a357-7a7c-8893-e6575aa4cb5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019fd8b5-a357-78c6-8000-db4d65eb9491" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019fd8b5-a357-78c6-8000-db4d65eb9491" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019fd8b5-a357-7a60-9a59-6e52863bc12b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019fd8b5-a357-7a60-9a59-6e52863bc12b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019fd8b5-a357-7f3d-9e05-325c88434b64" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019fd8b5-a357-7f3d-9e05-325c88434b64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019fd8b5-a357-726d-b4ad-c5fbdeeeda44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019fd8b5-a357-726d-b4ad-c5fbdeeeda44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019fd8b5-a357-73a3-b71c-3c0f38621967" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd8b5-a357-7dd0-b40c-efd7157f0895" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019fd8b5-a357-73a3-b71c-3c0f38621967" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/SelectedbalancesheetinformationScheduleofInventoryDetails" xlink:type="simple" xlink:href="cvrx-20260930.xsd#SelectedbalancesheetinformationScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/SelectedbalancesheetinformationScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd8b5-a357-750e-8213-13adecd40e42" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fd8b5-a357-7d3d-8e2e-f1a5213f251b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd8b5-a357-750e-8213-13adecd40e42" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fd8b5-a357-7d3d-8e2e-f1a5213f251b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd8b5-a357-76da-ba76-f0ab8d161bf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd8b5-a357-750e-8213-13adecd40e42" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd8b5-a357-76da-ba76-f0ab8d161bf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd8b5-a357-7dea-a525-bf77d9bc451f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd8b5-a357-750e-8213-13adecd40e42" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd8b5-a357-7dea-a525-bf77d9bc451f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/SelectedbalancesheetinformationScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="cvrx-20260930.xsd#SelectedbalancesheetinformationScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/SelectedbalancesheetinformationScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd8b5-a357-74d9-9ec2-7d0e1cdb44f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019fd8b5-a357-7518-9073-64b36b6a0295" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd8b5-a357-74d9-9ec2-7d0e1cdb44f4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019fd8b5-a357-7518-9073-64b36b6a0295" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019fd8b5-a357-7674-8610-53080925a2ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd8b5-a357-74d9-9ec2-7d0e1cdb44f4" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019fd8b5-a357-7674-8610-53080925a2ae" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/SelectedbalancesheetinformationScheduleofAccruedExpensesDetails" xlink:type="simple" xlink:href="cvrx-20260930.xsd#SelectedbalancesheetinformationScheduleofAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/SelectedbalancesheetinformationScheduleofAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_019fd8b5-a357-74cc-a80b-237c336862d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_us-gaap_AccruedBonusesCurrent_019fd8b5-a357-74cc-a80b-237c336862d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesCurrent_019fd8b5-a357-74ad-b16f-730c40c78446" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_us-gaap_PensionAndOtherPostretirementAndPostemploymentBenefitPlansLiabilitiesCurrent_019fd8b5-a357-74ad-b16f-730c40c78446" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cvrx_AccruedCustomerRebateCurrent_019fd8b5-a357-762f-ad1e-64acff713e9f" xlink:href="cvrx-20260930.xsd#cvrx_AccruedCustomerRebateCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_cvrx_AccruedCustomerRebateCurrent_019fd8b5-a357-762f-ad1e-64acff713e9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_019fd8b5-a357-76c2-bd1b-321ad0e64b45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_us-gaap_InterestPayableCurrent_019fd8b5-a357-76c2-bd1b-321ad0e64b45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019fd8b5-a357-79de-ac34-b29c426c8dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019fd8b5-a357-79de-ac34-b29c426c8dbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cvrx_AccruedPaidTimeOffCurrent_019fd8b5-a357-7f68-9042-d953f3e3c571" xlink:href="cvrx-20260930.xsd#cvrx_AccruedPaidTimeOffCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_cvrx_AccruedPaidTimeOffCurrent_019fd8b5-a357-7f68-9042-d953f3e3c571" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cvrx_ClinicalTrialAndOtherProfessionalFeesCurrent_019fd8b5-a357-75be-a8de-6dfda4eee30b" xlink:href="cvrx-20260930.xsd#cvrx_ClinicalTrialAndOtherProfessionalFeesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_cvrx_ClinicalTrialAndOtherProfessionalFeesCurrent_019fd8b5-a357-75be-a8de-6dfda4eee30b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019fd8b5-a357-704d-973b-fde9ab889613" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019fd8b5-a357-704d-973b-fde9ab889613" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019fd8b5-a357-776e-b131-cfc4f3267913" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd8b5-a357-7a2d-b3aa-faafddbf8f39" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019fd8b5-a357-776e-b131-cfc4f3267913" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/DebtScheduleofAnnualPrincipalMaturitiesofDebtDetails" xlink:type="simple" xlink:href="cvrx-20260930.xsd#DebtScheduleofAnnualPrincipalMaturitiesofDebtDetails"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/DebtScheduleofAnnualPrincipalMaturitiesofDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-735d-b0ae-7549714ec924" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019fd8b5-a357-74a5-ae28-1a7ff9e5fb94" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-735d-b0ae-7549714ec924" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019fd8b5-a357-74a5-ae28-1a7ff9e5fb94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019fd8b5-a357-7273-8f9b-043b9e34f4b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-735d-b0ae-7549714ec924" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019fd8b5-a357-7273-8f9b-043b9e34f4b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019fd8b5-a357-77e3-b9d8-316ffa9422ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-735d-b0ae-7549714ec924" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019fd8b5-a357-77e3-b9d8-316ffa9422ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019fd8b5-a357-70ad-ae65-ac1de609d588" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-735d-b0ae-7549714ec924" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019fd8b5-a357-70ad-ae65-ac1de609d588" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019fd8b5-a357-7152-a2b6-76e5990d20cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-735d-b0ae-7549714ec924" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019fd8b5-a357-7152-a2b6-76e5990d20cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cvrx_LongTermDebtMaturityAfterYearFour_019fd8b5-a357-718e-9e3f-927bfe110764" xlink:href="cvrx-20260930.xsd#cvrx_LongTermDebtMaturityAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-735d-b0ae-7549714ec924" xlink:to="loc_cvrx_LongTermDebtMaturityAfterYearFour_019fd8b5-a357-718e-9e3f-927bfe110764" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019fd8b5-a357-74dc-81a7-cc258f9937a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fd8b5-a357-7fd0-919d-bdefe81b4acf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019fd8b5-a357-74dc-81a7-cc258f9937a6" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019fd8b5-a357-7fd0-919d-bdefe81b4acf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-753f-adf6-9d128652a093" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019fd8b5-a357-74dc-81a7-cc258f9937a6" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019fd8b5-a357-753f-adf6-9d128652a093" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/LeasesLeaseBalancesWithintheCondensedConsolidatedBalanceSheetsDetails" xlink:type="simple" xlink:href="cvrx-20260930.xsd#LeasesLeaseBalancesWithintheCondensedConsolidatedBalanceSheetsDetails"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/LeasesLeaseBalancesWithintheCondensedConsolidatedBalanceSheetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_01a01aef-9c5f-74d7-a854-e4055027dab1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_01a01aef-9c5f-73a7-83d7-a7150e2f777d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_01a01aef-9c5f-74d7-a854-e4055027dab1" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_01a01aef-9c5f-73a7-83d7-a7150e2f777d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a01aef-9c5f-7ee6-8f59-f7915d23dc2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_01a01aef-9c5f-74d7-a854-e4055027dab1" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_01a01aef-9c5f-7ee6-8f59-f7915d23dc2d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/LeasesScheduleofMaturitiesofleaseliabilityDetails" xlink:type="simple" xlink:href="cvrx-20260930.xsd#LeasesScheduleofMaturitiesofleaseliabilityDetails"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/LeasesScheduleofMaturitiesofleaseliabilityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd8b5-a357-74c9-936b-1a9b93adfad5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019fd8b5-a357-7c9e-b433-1da2233c1088" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd8b5-a357-74c9-936b-1a9b93adfad5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019fd8b5-a357-7c9e-b433-1da2233c1088" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019fd8b5-a357-7396-a158-639aeb1c17ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd8b5-a357-74c9-936b-1a9b93adfad5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019fd8b5-a357-7396-a158-639aeb1c17ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019fd8b5-a357-786c-883c-86a46e60e6af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd8b5-a357-74c9-936b-1a9b93adfad5" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019fd8b5-a357-786c-883c-86a46e60e6af" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.cvrx.com/role/LeasesScheduleofMaturitiesofleaseliabilityDetails_1" xlink:type="simple" xlink:href="cvrx-20260930.xsd#LeasesScheduleofMaturitiesofleaseliabilityDetails_1"/>
  <link:calculationLink xlink:role="http://www.cvrx.com/role/LeasesScheduleofMaturitiesofleaseliabilityDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd8b5-a357-7754-81f2-8d5ddc88568f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019fd8b5-a357-7d41-b084-6840833df5a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd8b5-a357-7754-81f2-8d5ddc88568f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019fd8b5-a357-7d41-b084-6840833df5a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019fd8b5-a357-79c6-9d70-f79ec564ca4f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd8b5-a357-7754-81f2-8d5ddc88568f" xlink:to="loc_us-gaap_OperatingLeaseLiability_019fd8b5-a357-79c6-9d70-f79ec564ca4f" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
